Tutorial Puzzles
From FoldIt Wiki
Here you can see the original instructions of the intro puzzles.
Translations:
Contents |
[edit] Sidechains
Level 1-1: One Small Clash
This is a protein. We need your help to fold it into the right shape!
Get rid of the clash by clicking and dragging one of the sidechains away from the other.
Level 1-2: Swing It Around
You can't see the sidechains from this angle!
Click and drag on the white background to rotate the view. You can also move or zoom by holding ctrl or shift while you drag.
Level 1-3: Hide the Hydrophobic
The big hydrophobic sidechain is out in the open!
Orange sidechains should be kept surrounded. Hide it in the empty space in the protein's interior and move the blue hydrophilic away outside.
Level 1-4: Shake It Off
The backbone is red with clashes! Make it green.
The Shake Sidechains tool will try to find the best place for all the sidechains at once. Try it!
[edit] Backbone packing
Level 2-1: When Backbones Collide
This clash can't be fixed moving sidechains alone!
Click and drag on the big backbone to pull it.
Level 2-2: Close the Gap
This protein needs to be folded back together!
Bring the two halves close so the hydrophobics match up. Then try a Wiggle Backbone to let the backbone slowly relax into a better shape.
Level 2-3: Twin Pack
The curly helices are too far apart!
Pack the helices closely, so the hydrophobics are squished between them. Then Shake and Wiggle!
You're close to the guide!
Even if your score went down, try a Shake then Wiggle combination to get more points!
Level 2-4: Triple Packed
The hydrophobics in the center are exposed!
You can Freeze parts of the protein to hold them in place while you pull. Just hold shift and double click the area you want to Freeze.
As many have problems with this one, here is LennStar's guide, proofed to be working several times: If you have done anythink, restart the puzzle. (best from puzzle menu if you have rotated the view)
Now, as the puzzle is fresh, do it this way: Take the lonely upper helix at the point where the arrow from the hint is pointing. Now move the mouse down-left to the red balls. (the voids, if you don't see them, either activate them in the views options, or target the one red hydrophobic in the foreground)
If a clash appears, pull a little bit more and stop. Now shake and wiggle. That should do the trick. Congratulations!
[edit] Hydrogen Bonding
Level 3-1: Sheets Together
This protein is made of two flat sheets.
Pull those sheets together! They like that.
Level 3-2: Lonely Sheets
Two little sheets, lost and alone...
Help them find each other with a Rubber Band: hold down shift while you click on one sheet and drag to the other. Wiggle to start them moving.
Level 3-3: Sheets and Ladders
Three sheets have been torn apart!
Rubber Band them together with a shift click drag. Once they are close enough, you can remove the bands and Wiggle again.
Level 3-4: Lock and Lower
One of the sheets is out of place!
Rubber bands can keep the sheets connected. Remember you can also shift click to Freeze, and Shake and Wiggle once they are close enough.
[edit] Tweak and Rebuild
Level 4-1: Turn It Down
The helix has turned and exposed a hydrophobic!
Rotate it back into place with the Tweak tool. You'll see it when you ctrl click on the helix.
You've started a Tweak!
Click and hold on the purple arrows to rotate the protein in the direction you want it to go.
Watch your score! If you turn it too far, you can try turning it back or just Undo.
Level 4-2: The Right Rotation
Find the one helix that needs rotating and fix it with the Tweak tool!
Look for a hydrophobic sticking out in the open, and turn it back in. You can always Undo.
Level 4-3: Flippin' Sheets
One of the sheets is twisted the wrong way!
Look for the sheet with the exposed hydrophobics, and click the new straight arrows on the Tweak tool to shift and flip it.
You've started a Tweak!
Click and hold on the curved purple arrows to rotate the protein in the direction you want it to go or use the straight purple arrows to shift and flip the sheet in that direction.
Watch your score! If you turn it too far, you can try turning it back or just Undo.
LennStar's guide: This is one puzzle that really dislikes being mishandled. It took me at least 5 tries. This is how to do it: If you already have done anything to it, reset the puzzle. (Hint: You propably have to move the 4 sheets to the foreground, the one with the arrow pointing on with the short end to the left. You can also go back to puzzle menu to get the right view.)
Now right click on the one sheet where the arrow from the text points to. Click tweak. Now click one time on the straight arrow to the right. Now the sheet should flip. use shake and wiggle it. That should raise your score to the needed points.
Level 4-4: Rebuild Repairs
The red loop is stuck in the wrong shape!
Try using the Rebuild tool to open up that loop. You'll see it when you ctrl click on the loop.
You've started to Rebuild the backbone!
The protein will try out some different shapes.
Once it looks good enough, click Stop Rebuild and try a Shake and Wiggle to get rid of clashes.
Level 4-5: Rubber Band Reversal
A hydrophobic is flipped the wrong way!
Reverse the zig zag with two Rubber Bands and a Rebuild: one band to bring the hydrophobic down, and another to bring the hydrophilic up. You can attach a Rubber Band to empty space!
[edit] Final Touches
Level 5-1: Almost there
The protein looks good, but Wiggle is stuck!
Nudge it just enough for Shake and Wiggle to push your points over the edge.
Level 5-2: The Last Few Points
Pack those helices to max out your score!
Keep an eye out for red or brown parts of the backbone that you can adjust for more points.
Level 5-3: The Final Challenge
Fold this and you're ready to compete in the real Science Puzzles!
Line up the sheets, pack the helices. You know the drill.
