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Mason-Pfizer Monkey Virus

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3SQF

The solution to puzzle 390, published as PDB id 3SQF

Solving a Mason-Pfizer monkey virus (M-PMV) protein helped establish Foldit as a serious science tool.

The protein in question, a retroviral protease, had been known for 15 years. It had been solved by NMR (nuclear magnetic resonance) in 2003, but the NMR results were inconsistent with results from X-ray crystallography.

Puzzle 390 launched 17 December 2010, and completed 7 January 2011. Using 10 starting models taken from NMR results, Foldit players were able to determine the correct native structure of the protein.

The puzzle used the alignment tool which allowed players to use partial threading to select portions of different models.

The Foldit Contenders group was listed as one of the authors of the paper "Crystal structure of a monomeric retroviral protease solved by protein folding game players", published in Nature Structural & Molecular Biology in 2011. See the complete paper.

The contributions of Contenders players spvinvent, grabhorn, and mimi are described in one of the figures.

(The Void Crushers group is also an author of the paper, and the group's CASP 9 work is discussed.)

The Contenders were also cited on the PDB entry: 3SQF. (The divergent NMR results are available as PDB entry 1NSO.)

The results are also referenced in a couple of Foldit blog posts: Recent Exciting Discoveries by Foldit and Nature Structural & Molecular Biology paper online!.

The protein was posted again in Puzzle 460, as a quest to the native" (QTTN) puzzle.

This protein was also revisited in Puzzle 712, but for some reason, no images were captured for the wiki. 3SQF Page.v3

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