Lock

From FoldIt Wiki

Lock structure is a tool that prevents a segment of a protein from moving during rebuilding and pulling. Lock structure can be applied at four different scales: the entire protein may be locked (hotkey: L); an individual structure may be locked (right-click and select from pie menu); a single amino acid may be locked (shift-click); and even a single sidechain can be locked (shift-click). When a structure is locked it changes into a light blue color and is translucent. This tool is used to isolate parts of proteins for use with other tools.

Contents 1 Locking and the Pull Tool 2 Locking and the Wiggle Tool 3 Locking and the Rebuild Tool 4 Locking and the Shake Sidechains Tool

[edit] Locking and the Pull Tool

When using the pull tool locked areas of proteins will not move. When lock is used globally the pull tool does nothing because there is nothing that is unlocked to pull. The pull tool can be used to move discrete parts of a protein separated from one another by a lock or locks; only sections that are connected to the place you click and drag from that are not separated by a locked section will be affected.

[edit] Locking and the Wiggle Tool

The wiggle tool when applied globally moves locked sections without there being any difference from when the sections are not locked. However when local wiggle is used it will affect the structure selected and wiggle all of the amino acids up to end at the point where the structure changes or where an amino acid is locked. This means that by placing a lock at any given point on a structure players may isolate the area which is wiggled to between a lock and the end of a structure or between two locks. When isolating sections of a protein for use with local wiggle, players most often change the entire protein to have only loop structures. The most notable use for this isolation is local wiggle strategy.

[edit] Locking and the Rebuild Tool

Locks can be used with the rebuild tool in a way similar to that described in the section above. The rebuild tool will affect a section until there is a change in structure or until there is a lock. Players use locks on single amino acids to choose a specific section to rebuild.

[edit] Locking and the Shake Sidechains Tool

Shake sidechains will not change the position of any locked sidechains.