FANDOM


Intro Success

Success!

Intro Puzzles are an easy introduction to how to fold proteins in Foldit.

As of June, 2018, intro levels and puzzles are no longer numbered, and the sequence of puzzles has changed.

Try to complete each puzzle without help first. Most of the puzzles should take only a couple of minutes. If you get stuck, use "Reset Puzzle" from Actions menu in the lower left and try again.

If you're having problems, you'll find tips below. Just click on the icon for the puzzle you're stuck on. There are tips and techniques for each puzzle. Each puzzle also YouTube videos provided by Foldit players Madde and Loci. There are also some general tips on how to navigate in Foldit.

A few puzzles, such Remix, Electron Density, and Hydrophobic Disaster, may require more time. These intro puzzles are closer to real Foldit puzzles.

If you have additional questions, ask online in the Foldit client using "Chat - Global", or "Chat - Group". See Foldit chat for more on Foldit chat. The following translations of this page are available: Deutsch | Svenska | Español | German | Russian | Japanese.

Intro puzzles are organized into levels. Click on the icons below for more information about each intro puzzle. The Intro Puzzle Master List has the same information in a simplified format.

Sidechains

The puzzles in the Sidechains level introduce sidechains and demonstrate ways to fix clashes. The shake tool makes its debut.

Backbone Packing

The Backbone Packing level introduces the backbone, the part which holds the protein together. The sidechains are attached to the backbone.

This level demonstrates how to fix voids. The wiggle tool is added to the mix. Wiggle and shake are the most important tools in Foldit.

Hydrogen Bonding

The Hydrogen Bonding level introduces hydrogen bonds, which help hold proteins together. Hydrogen bonds show as blue-and-white "candy canes" in Foldit.

This level includes techniques for lining up sheets that are used all the time by Foldit players. It adds bands, which are important for moving sheets and other parts of the protein.

Hydrophobics and Hydrophilics

This level discusses hydrophobics and hydrophilics in more detail. Orange sidechains are hydrophobic, and should be hidden on the inside of the protein. Blue sidechains are hydrophilic, and are OK on the outside of the protein.

Tools and Types

The Tools and Types level introduces some of the different puzzle types found in Foldit. The move tool is added.

This level also introduces the remix tool, which searches for new shapes for your protein.

Sequences

Sequences introduces the alignment tool. The alignment tool lets you apply the shapes of other proteins to the protein you're working on.

You'll also get to use cuts, which chop a protein into pieces. Cuts are used in all kinds of ways in Foldit.

Conditions

This level covers conditions, which enforce special rules on some puzzles. Conditions may change your score, adding or subtracting points. Conditions were previously called "filters".

Blueprint

This level introduces the blueprint tool, which is used in design puzzles to insert shapes found in natural proteins. The blueprint tool may help players create proteins which fold up on their own like natural ones. Design puzzles are covered in more detail in the next section.

Protein Design

This level introduces Foldit design puzzles, which give players the chance to design new proteins. Some of these designs actually get turned into real proteins in the Foldit lab, see design puzzle results for more.

More Molecules

The More Molecules level introduces ligands. A ligand is a non-protein atom or molecule. A ligand can be as small as copper or calcium atom, or as large as a strand of DNA.

These puzzles work with fixed ligands that can't be changed. A new small molecule design feature is in development for Foldit. This will allow the ligand to be designed, much as current designs puzzles allow proteins to be designed.