Global Lock/Wiggle Strategy is an initial start through endgamestrategy popularized by the player lou that has since gained a widespread following. It consists of the following steps:
Freeze the entire puzzle. Use the lowercase "f" keyboard shortcut to freeze the entire protein - backbone and sidechains.
There are two ways to go on this strategy. One is to start a global wiggle.
Gradually unfreeze selected areas, usually in small sections (2-5 segments plus sidechains). Remember, sidechains also get frozen with a global freeze so you may want to individually unlock them.
Move around the puzzle selecting different sections. If the score decreases, you can't stop and undo like Sirenbrian's Local Wiggle Strategy, but you can stop the wiggle and restore best and lock that section before continuing. The objective is to get a good backbone start before a lot of pulling, so keep working around the puzzle.
Note where you find good release points. You'll see a big jump or reduction in score there. Once your puzzle is set later, those may be good choices for tweaks.
After you have unfrozen all the sections, unfreeze everything (you can use the lowercase "f" key to unfreeze the entire puzzle including sidechains) and do a Shake Sidechains and then a global wiggle. Try the shake and wiggle combination until your points run out. You can also pull after the unlock before trying combinations of Shake Sidechains and global Wiggle.
The second method is to freezethe puzzle and select small portions to unfreexze and then use the local wiggle. Essentially this is like the Local Wiggle Strategy except the sidechains may be frozen. The locking of the entire puzzle gives a good visual aid to where you have unlocked.