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Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about The Science Behind Foldit.

New Players

Visit the fold.it, the official Foldit site to download the game and get started. Foldit runs on Windows, Mac, and 64-bit Linux. See Download-Install-Troubleshoot for install instructions. Use the feedback page if you're having trouble getting the game installed.

The Intro Puzzles show you the tools, try them before trying a science puzzle. (deutsch) | (svenska)

See Get Started Playing Foldit for more.

Please read the Foldit Community Guidelines and Terms of Service.

See Foldit Status for any issues affecting the game.

Updates

  • Pretty sketchy: for players overwhelmed by the new megapuzzles, the Sketchbook puzzle is back. Puzzle 1442 crosses a sketchbook puzzle with a revisiting puzzle, looking a small protein seen earlier this year in Puzzle 1415.
  • Don't cross the streams: two foldistas have taken to live-streaming on Twitch. Check out previous videos from S0ckrates and Susume. You can follow them on Twitch to be notified when they go live. S0ckrates has generally been streaming live Friday afternoons, US Pacific time. Both have been announcing their live streams on Foldit chat.
  • You asked for it: a new era of Foldit seems to be upon us. The Aflatoxin Challenge has launched, starting with Puzzle 1440. Look for more puzzles in this series going forward. Like 1440, the other two science puzzles are also extra-large. Puzzle 1441 is similar to puzzle 1440, having multiple locked sections and permanent cutpoints, but also brings back the multi-start feature. (Resetting the puzzle gives you a different starting structure.) Puzzle 1438 is just a standard de-novo, but extra-large, with extra time granted. Revisiting and monomer design puzzles are resting at the moment, but of course they may be back some day.
  • Mystic crystal revelation: a protein designed by Foldit players has been successfully crystallized, and the crystal structure has been solved by X-ray diffraction. Puzzle 1384 presents this protein as an electron density puzzle. See protein crystallization and design updates Part 1 and Part 2 for more.

Videos

David Baker (U14:42

David Baker (U. Washington HHMI) Crowd Sourcing Protein Folding Rosetta@Home and FoldIt


Tools, tips, techniques

Several translations of the Foldit Wiki are available:
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Featured articles

Contents   ( View All Pages - Foldit Wikia Index )


Helping out

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