Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about The Science Behind Foldit.
Visit the fold.it, the official Foldit site to download the game and get started. Foldit runs on Windows, Mac, and 64-bit Linux. See Download-Install-Troubleshoot for install instructions. Use the feedback page if you're having trouble getting the game installed. If you're seeing "error contacting server" messages, update this feedback with details.
See Get Started Playing Foldit for more.
See Foldit Status for any issues affecting the game.
- Coming soon to a Foldit near you: the experimental update group will replace main and devprev sometime in the day on Tuesday, 13 March, Seattle time, according the recent Science Chat. All puzzles will end before the update is released, and then new puzzles will require the update. This approach avoids problems when opening shared solutions in different releases. See New Update in 'Experimental' Update Group! for more on the changes in this release.
- There's a word for that: check out Foldit in 20 words for a quick tour.
- Oh no, not again! Once again, a protein designed by Foldit players has been successfully crystallized, and the crystal structure has been solved by X-ray diffraction. This time, the nod goes to tokens, for a top-scoring solution to Puzzle 1313. We've already had this protein as de-novo in Puzzle 1452, and now it's back again as an electron density in Puzzle 1475. See design puzzle results for more.
- Details, details: all of the functions in the Foldit Lua interface now have their own detail page. See Foldit Lua functions for the complete list. Check out the updated page for the ultra-complex band.Add.
- FolditatUW - foldit's official YouTube channel.
- P1 - Introduction to Protein Design (15m)
- P2 - Design of New Protein Functions (27m)
- Beta_Helix's Foldit video the basics explained (40m)
- Through the eyes of a scientist Design solutions reviewed (26m)
- Design solutions reviewed Part 2 (22m)
- As seen on TV: Origami Revolution. Nova on PBS featured protein folding, David Baker, Rosetta@Home and Foldit. (Minutes 20 through 28, with Foldit briefly mentioned at 23:45.)
Tools, tips, techniques
- Foldit 101 - Useful information about Puzzle Types, the Cookbook and recipe basics.
- How to get started - With pictures from an actual puzzle
- Puzzle Results - screen shots of top scoring and interesting player solutions.
- Blackbelt Folding - Sessions 1,2, 3 & 4 denovo
- Electron Density - info and videos
- Hydrogen Bond Networks
- Download-Install-Troubleshoot includes Tracks, devprev and using multiple clients on Windows, Mac and Linux
- Foldit chat (IRC)
- Frequently asked questions
- Foldit Accessibility
- Foldit Translations
- Strategy - how to improve your score
- TheGame - tools, score details and Lua scripting
- Groups-Players - groups (teams), players and a bit of humour.
- The Research Room - advanced discussions and lots of external links
- Scientist and Developer Chats
- Hydrogen Bond Networks
- Small molecule design puzzles
- Interesting Articles
Contents ( View All Pages - Foldit Wikia Index )
These pages describe the science of protein folding.
- Primary Structure
- Secondary Structure
- Hydrophilic and Hydrophobic (also known as "blue out, orange in")
- Protein Folding Theory
- Biochemistry I
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