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Foldit is an online game in which humans try to solve one of the hardest computational problems in biology: protein folding. You don't need to know anything about biology to play the game, although a little background will help. Most Foldit player are not biologists. Read about The Science Behind Foldit.

New Players

Visit the fold.it, the official Foldit site to download the game and get started. Foldit runs on Windows, Mac, and 64-bit Linux. See Download-Install-Troubleshoot for install instructions. Use the feedback page if you're having trouble getting the game installed.

The Intro Puzzles show you the tools, try them before trying a science puzzle. (deutsch) | (svenska)

See Get Started Playing Foldit for more.

Please read the Foldit Community Guidelines and Terms of Service.

See Foldit Status for any issues affecting the game.

Updates

  • Think small: Puzzle 1432 launches the Small Molecule Design category, targeting HIV protease, as described in a Foldit blog post. (Small molecule design was previously referred to a "drug design".)
  • Conditional love, mojo filter: also in the latest developer preview release, the term "condition" has started to replace "filter". (There's still some work to be done, both in Foldit and here in wikiville.)
  • Tokens effort: New videos from tokens show how to use the Rama map on de-novo puzzles 1335 and 1375. (Both puzzles were based on Foldit designs.)
  • Mystic crystal revelation: a protein designed by Foldit players has been successfully crystallized, and the crystal structure has been solved by X-ray diffraction. Puzzle 1384 presents this protein as an electron density puzzle. See protein crystallization and design updates Part 1 and Part 2 for more.
  • Fast Foldit: watch a 2 minute 30 second Foldit video, part of the 2017 NSF STEM for All Video Showcase.

Videos

David Baker (U14:42

David Baker (U. Washington HHMI) Crowd Sourcing Protein Folding Rosetta@Home and FoldIt


Tools, tips, techniques

Several translations of the Foldit Wiki are available:
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Featured articles

Contents   ( View All Pages - Foldit Wikia Index )


Helping out

This is a wiki about the Foldit game that anyone can edit. Before you do edit it, however, please take a look around and determine whether or not the article you'd like to write already exists. (If it does exist, feel free to make it better!)

To write a new article, just enter the article title in the box below.

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  • Check out the community portal to see what the community is working on, to give feedback or just to say hi.

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