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Scorpion toxins have been a popular subject for Foldit puzzles. They tend to fold into structures with many disulfide bridges, three beta sheets, and an alpha helix. The wikipedia article scorpion toxin is a good place for examples.

Three different scorpion toxins are regularly seen as revisiting puzzles. See Revisiting Puzzle: Scorpion Toxin for details.

A classic of Foldit!

New player puzzle[]

The toxin in the early Foldit puzzle seen here is from Pandinus imperator, and has only 35 residues with the sequence:

tisctnpkqcyphckketgypnakcmnrkckcfgr

It is shorter than the usual three-sheet toxins.

This sequence is found in the PDB as 2PTA.

The protein can have three disulfide bridges, at 7-28, 13-33, and 17-35.

This protein was last seen in New Player Puzzle 2: Scorpion Toxin in 2011.

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