Fandom

Foldit Wiki

Disulfide Bridge

1,290pages on
this wiki
Add New Page
Comment1 Share

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

A disulfide bridge is formed when a sulfur atom from one Cysteine forms a single covalent bond with a sulfur atom from a second Cysteine in a different part of the protein. This bond is termed a Disulfide Bridge; these bridges help to stabilize proteins, especially those secreted from cells. The presence of a pair of Cysteines in a protein indicates the possibility (but not the requirement) of a disulfide bridge.
Disulfilte

disulfide bridge

Unlike a Hydrogen Bond, a disulfide bridge was not shown in the first implementation of FoldIt. Manipulating Cysteine sidechains so that their ends point toward one another has sometimes been noticed to yield points, but as it turns out, the developers have confirmed that this effect is unrelated to the disulfide bridge. As of the past implementation, disulfide bridges do not seem to be scored in FoldIt.

Starting in January 2012, disulfide bridges are enabled in ALL puzzles by default.

To see them click on Show bonds (sidechains) in View options (V). First get the advanced GUI iin the general options.

More information can be found at http://en.wikipedia.org/wiki/Disulphide_bridge

Also on Fandom

Random Wiki